6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride manufacturers
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| | 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Basic information |
| Product Name: | 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride | | Synonyms: | 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride | | CAS: | 91574-89-9 | | MF: | C27H32ClNO3 | | MW: | 454.00088 | | EINECS: | 2938425 | | Product Categories: | | | Mol File: | 91574-89-9.mol | ![6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Structure](CAS/GIF/91574-89-9.gif) |
| | 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Chemical Properties |
| | 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Usage And Synthesis |
| Originator | Asocainol,ZYF Pharm | | Manufacturing Process | A solution of a Grignard reagent is prepared from 5.5 g (0.23 mol) activated
magnesium turnings and 41.5 g (0.24 mol) phenethyl bromide in 200 ml
anhydrous diethyl ether. To this is added dropwise, at 35-40°C, a solution of
31.5 g (0.1 mol) thebaine in 0.4 liters dry benzene. After heating under reflux
for 2 hours, the reaction mixture is decomposed with a solution of 48 g
ammonium chloride in 200 ml water. The usual working up, after conversion
of the base into the hydrochloride by means of hydrogen chloride in ethyl
acetate, gives 7.3 g (21% of theory) (+/-)-2,12-dimethoxy-1-hydroxy-7-
methyl-6-phenethyl-5,6,8,9-tetrahydro-7H-dibenz[d,f]azonine hydrochloride,
melting point 227.6°C, after recrystallization from propan-2-ol. | | Therapeutic Function | Antiarrhythmic |
| | 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Preparation Products And Raw materials |
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