hydrocotarnine manufacturers
- hydrocotarnine
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- $41.00
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2026-08-20
- CAS:550-10-7
- Purity: 99.31%
- Supply Ability: 10g
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| | hydrocotarnine Basic information |
| Product Name: | hydrocotarnine | | Synonyms: | 1,2,3,4-Tetrahydro-2-methyl-6,7-(methylenebisoxy)-8-methoxyisoquinoline;4-Methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline;5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline;Hydrocotarnine Hydrochloride;4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline hydrate hydrochloride;4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinoline;Noscapine Impurity 3(Hydrocotarnine);1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl- | | CAS: | 550-10-7 | | MF: | C12H15NO3 | | MW: | 221.25 | | EINECS: | 208-978-2 | | Product Categories: | | | Mol File: | 550-10-7.mol |  |
| | hydrocotarnine Chemical Properties |
| Melting point | 56°C | | Boiling point | 362.31°C (rough estimate) | | density | 1.1514 (rough estimate) | | refractive index | 1.5200 (estimate) | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | form | Solid | | pka | 7.75±0.20(Predicted) | | color | Light Brown to Orange |
| | hydrocotarnine Usage And Synthesis |
| Uses | Hydrocotarnine Hydrochloride, is an oxidative degradation product of the drug Noscapine (128-62-1). | | Definition | ChEBI: 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline is a member of isoquinolines. | | in vivo | Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) shows inhibitory effect on Cbl and results in increasing IL-18 levels, indicating that NLRP3 inflammasome activation is enhanced in mice[1].
Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) protects mice from DSS-induced colitis, with low scores of pathological evaluation of inflammation, epithelial defects, and crypt atrophy[1]. | Animal Model: | DSS-induced colitis model in C57BL/6 mice (6-9 weeks old)[1] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; once daily; 9 days while 2.5% DSS treatment began on day 1 and ended on day 7 | | Result: | Significantly attenuated the weight loss of DSS-induced colitis mice compared to PBS-treated control mice, indicating that decreasing negative regulation of the NLRP3 inflammasome activation could attenuate colitis in an animal model.
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| | hydrocotarnine Preparation Products And Raw materials |
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