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9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)-

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9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:SR-1277
CAS:1446715-47-4
Package:25mg/RMB 10600
9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)- Basic information
Product Name:9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)-
Synonyms:9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)-;SR-1277
CAS:1446715-47-4
MF:C21H19N9O3S
MW:477.5
EINECS:
Product Categories:
Mol File:1446715-47-4.mol
9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)- Structure
9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)- Chemical Properties
Boiling point 893.2±75.0 °C(Predicted)
density 1.73±0.1 g/cm3(Predicted)
pka7.29±0.30(Predicted)
Safety Information
MSDS Information
9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)- Usage And Synthesis
DescriptionML177 is a potent, selective and ATP competitive CK1δ/ε inhibitor.
UsesSR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1].
in vivo

SR-1277 (1 mg/kg; i.v.) exhibits Cmax (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM h), T1/2 (1.42 h) and brain penetration (24%) in mice[1].

IC 50CKIδ: 49 nM (IC50)
References[1] Bibian M, et, al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. DOI:10.1016/j.bmcl.2013.05.075
9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)- Preparation Products And Raw materials
Tag:9H-Purin-6-amine, 2-(4-morpholinyl)-N-[(7-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thienyl)-(1446715-47-4) Related Product Information
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