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| | 2,2,2-trifluoroacetic acid Basic information |
| Product Name: | 2,2,2-trifluoroacetic acid | | Synonyms: | (2S)-2-[[2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]butanedioic acid;Arg-Gly-Asp (trifluoroacetate salt);L-Aspartic acid, N-(N-L-arginylglycyl)-, trifluoroacetate | | CAS: | 120103-89-1 | | MF: | C14H23F3N6O8 | | MW: | 460.37 | | EINECS: | | | Product Categories: | | | Mol File: | 120103-89-1.mol |  |
| | 2,2,2-trifluoroacetic acid Chemical Properties |
| storage temp. | -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid |
| | 2,2,2-trifluoroacetic acid Usage And Synthesis |
| Uses | Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1. It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo. | | Biological Activity | Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1.1,2 It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.2,3 | | References | 1.Ruoslahti, E.RGD and other recognition sequences for integrinsAnnu. Rev. Cell Dev. Biol.12697-715(1996)
2.Danhier, F., Le Breton, A., and Préat, V.RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosisMol. Pharm.9(11)2961-2973(2012)
3.Schottelius, M., Laufer, B., Kessler, H., et al.Ligands for mapping αvβ3-integrin expression in vivoAcc. Chem. Res.42(7)969-980(2009) |
| | 2,2,2-trifluoroacetic acid Preparation Products And Raw materials |
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