AC-ASP-LEU-SER-D-PHE-HIS-N-ME-LEU-LEU-ARG-LYS-NLE-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-Γ-GLU-ASN-ASN-Ε-LYS-LEU-LEU-LEU-ASP-N-ME-LEU-ILE-OH(LACTAM BRIDGE = GLU24-LYS27)
| 中文名称 | AC-ASP-LEU-SER-D-PHE-HIS-N-ME-LEU-LEU-ARG-LYS-NLE-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-Γ-GLU-ASN-ASN-Ε-LYS-LEU-LEU-LEU-ASP-N-ME-LEU-ILE-OH(LACTAM BRIDGE = GLU24-LYS27) |
|---|---|
| 中文同义词 | AC-ASP-LEU-SER-D-PHE-HIS-N-ME-LEU-LEU-ARG-LYS-NLE-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-Γ-GLU-ASN-ASN-Ε-LYS-LEU-LEU-LEU-ASP-N-ME-LEU-ILE-OH(LACTAM BRIDGE = GLU24-LYS27);化合物 ASTRESSIN 2B |
| 英文名称 | ASTRESSIN2B TRIFLUOROACETATE SALT |
| 英文同义词 | Cyclo(31-34)[D-Phe11,His12,C(α)MeLeu13,39,Nle17,Glu31,Lys34]Ac-Svg(8-40) trifluoroacetate salt |
| CAS号 | 681260-70-8 |
| 分子式 | C183H307N49O53 |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
AC-ASP-LEU-SER-D-PHE-HIS-N-ME-LEU-LEU-ARG-LYS-NLE-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-Γ-GLU-ASN-ASN-Ε-LYS-LEU-LEU-LEU-ASP-N-ME-LEU-ILE-OH(LACTAM BRIDGE = GLU24-LYS27) 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 膜状 |
| 颜色 | 无色 |
| 水溶解性 | Soluble to 1 mg/ml in water |
| 序列 | Ac-Asp-Leu-Ser-{d-Phe}-His-{a-methyl-Leu}-Leu-Arg-Lys-{Nle}-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-{g-Glu}-Asn-Asn-Leu-Leu-Leu-Asp-{a-methyl-Leu}-Ile-NH2 (Lactam bridge: Glu24-Lys27) |
AC-ASP-LEU-SER-D-PHE-HIS-N-ME-LEU-LEU-ARG-LYS-NLE-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-Γ-GLU-ASN-ASN-Ε-LYS-LEU-LEU-LEU-ASP-N-ME-LEU-ILE-OH(LACTAM BRIDGE = GLU24-LYS27) 用途与合成方法
Astressin 2B 是一种有效的选择性的促肾上腺皮质激素释放因子受体2 (corticotropin-releasing factor receptor 2 (CRF2)) 拮抗剂，对 CRF2 和 CRF1的 IC50 值分别为 1.3 和 > 500 nM。Astressin 2B 拮抗 CRF2 介导的胃排空抑制。
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |