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| | PSI trifluoroacetate salt Basic information |
| | PSI trifluoroacetate salt Chemical Properties |
| solubility | Formic Acid: 1 mg/ml |
| | PSI trifluoroacetate salt Usage And Synthesis |
| Description | PSI is a synthetic peptide proteasome inhibitor.1,2,3 It inhibits the acidic and neutral chymotrypsin-like activities of the 20S proteasome (IC50s = 0.25 and 6.5 µM, respectively).3 PSI is cytotoxic to HL-60, KG-1a, RWLeu-4, AR230, and K562 human leukemia cells (IC50s = 4.9, 17.5, 7.8, 7.3, and 10 nM, respectively).4 It selectively induces apoptosis in subconfluent bovine aortic endothelial cells (BAECs) and human umbilical vein endothelial cells (HUVECs; EC50s = 24 and 7 nM, respectively) over confluent BAECs and HUVECs (EC50s = 8,150 and 7,830 nM, respectively).5 PSI induces accumulation of ubiquitin-protein conjugates in HT4 mouse neuronal cells.6WARNING This product is not for human or veterinary use. | | References | [1] GALEN ANDREW COLLINS Alfred L G. The Logic of the 26S Proteasome.[J]. Cell, 2017, 169 5: 792-806. DOI: 10.1016/j.cell.2017.04.023
[2] MARIAN ORLOWSKI Sherwin W. Catalytic Activities of the 20 S Proteasome, a Multicatalytic Proteinase Complex[J]. Archives of biochemistry and biophysics, 2000, 383 1: Pages 1-16. DOI: 10.1006/abbi.2000.2036
[3] FIGUEIREDOPEREIRA M.E. A Novel Chymotrypsin like Component of the Multicatalytic Proteinase Complex Optimally Active at Acidic pH[J]. Archives of biochemistry and biophysics, 1995, 317 1: Pages 69-78. DOI: 10.1006/abbi.1995.1137
[4] DAVIDE SOLIGO. The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI[J]. British Journal of Haematology, 2002, 113 1: 126-135. DOI: 10.1046/j.1365-2141.2001.02683.x
[5] HANNES C. A. DREXLER MORITZ A K WERNER RISAU. Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells[J]. FASEB Journal, 2000, 14 1: 65-77. DOI: 10.1096/fasebj.14.1.65
[6] MARIA E. FIGUEIREDO-PEREIRA Sherwin W Kelly A Berg. A New Inhibitor of the Chymotrypsin-Like Activity of the Multicatalytic Proteinase Complex (20S Proteasome) Induces Accumulation of Ubiquitin-Protein Conjugates in a Neuronal Cell[J]. Journal of Neurochemistry, 1994, 63 4: 1578-1581. DOI: 10.1046/j.1471-4159.1994.63041578.x |
| | PSI trifluoroacetate salt Preparation Products And Raw materials |
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