2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]-

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2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]- Basic information
Product Name:2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]-
Synonyms:2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]-;BMS-185354
CAS:110952-22-2
MF:C26H27NO3
MW:401.5
EINECS:
Product Categories:
Mol File:110952-22-2.mol
2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]- Structure
2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]- Chemical Properties
Boiling point 578.7±50.0 °C(Predicted)
density 1.17±0.1 g/cm3(Predicted)
pka4.10±0.30(Predicted)
Safety Information
MSDS Information
2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]- Usage And Synthesis
UsesBMS-185354 is a selective RARγ activator with an EC50 value of 28 nM. BMS-185354 is promising for research of cancers[1].
IC 50RXRγ: 28 nM (EC50)
References[1] Ostrowski J, et al. Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes. J Biol Chem. 1998 Feb 6;273(6):3490-5. DOI:10.1074/jbc.273.6.3490
2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]- Preparation Products And Raw materials
Tag:2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]-(110952-22-2) Related Product Information
Ro 41-5253 AGN 194310 TTNPB (Arotinoid Acid) 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid 4-Hydroxyphenylretinamide Retinoic acid