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| | Cyclopropaneacetic acid, α-hydroxy-, phenylmethyl ester, (αS)- Basic information |
| | Cyclopropaneacetic acid, α-hydroxy-, phenylmethyl ester, (αS)- Chemical Properties |
| Boiling point | 326.2±17.0 °C(Predicted) | | density | 1.234±0.06 g/cm3(Predicted) | | pka | 12.90±0.20(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | Cyclopropaneacetic acid, α-hydroxy-, phenylmethyl ester, (αS)- Usage And Synthesis |
| Uses | (S)-Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate reactant in the synthesis of Camptothecin (HY-16560). Camptothecin is an inhibitor of the DNA topoisomerase Topo I, withIC50=679 nM[1][2]. | | References | [1] Li Zhen, et al. Camptothecin derivative, and pharmaceutical composition and use thereof. World Intellectual Property Organization, WO2023020605 A1. 2023-02-23.
[2] Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem. 2013;63:746-757. DOI:10.1016/j.ejmech.2013.01.058 |
| | Cyclopropaneacetic acid, α-hydroxy-, phenylmethyl ester, (αS)- Preparation Products And Raw materials |
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