NETAMIFTIDE
| 中文名称 | NETAMIFTIDE |
|---|---|
| 中文同义词 | NEMIFITIDE DITFA;FLUORO-PHE-HYP-ARG-GLY-TRP-NH2;五肽INN 00835;多肽NEMIFITIDE三氟乙酸盐 |
| 英文名称 | NETAMIFTIDE |
| 英文同义词 | Bis(trifluoroacetate);Netamiftide ditriflutate;NETAMIFTIDE;(2S)-N-[(1S)-1-[[(1S)-1-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoylmethylcarbamoyl]-4-(diaminomethylideneamino)butyl]-4-hydroxy-pyrrolidine-2-carboxamide;Nemifitide diTFA;INN 00835 diTFA;Nemifitide di;Nemifitide Ditriflutate |
| CAS号 | 204992-09-6 |
| 分子式 | C35H44F4N10O8 |
| 分子量 | 808.79 |
| EINECS号 | |
| 相关类别 | 多肽 |
| Mol文件 | 204992-09-6.mol |
| 结构式 |  |
NETAMIFTIDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Water: 250 mg/mL (270.91 mM) |
| 序列 | {Fluoro-Phe}-{Hyp}-Arg-Gly-Trp-NH2 |
Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽抗抑郁药，具有迅速起效的潜力。Nemifitide diTFA 是黑色素细胞抑制因子 (MIF) 的肽类似物。Nemifitide diTFA 可以透过血脑屏障。
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin.
Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.
| Animal Model: | Male Flinders Sensitive Line (FSL) rat weighing 280-320 g |
| Dosage: | 0.3 mg/kg |
| Administration: | IP; daily; for 14 days |
| Result: | Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 5mg | 2500元 |
| 2025/12/22 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 10mg | 4500元 |