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| Products Intro: |
Product Name:Fluorouracil Impurity 16
CAS:2440-60-0
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
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| | o-methylisourea Basic information |
| Product Name: | o-methylisourea | | Synonyms: | o-Methylisouronium;o-methylisourea;ORTHO-METHYLISOUREA;Carbamimidic acid methyl ester;Methoxyformamidine;o-methylisourea (abbreviate OMIU);Carbamimidic acid,methyl ester (9CI);Methyl carbamimidate | | CAS: | 2440-60-0 | | MF: | C2H6N2O | | MW: | 74.08 | | EINECS: | | | Product Categories: | | | Mol File: | 2440-60-0.mol |  |
| | o-methylisourea Chemical Properties |
| Melting point | 44-45 °C | | Boiling point | 66.9±23.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | solubility | free base readily sol most organic solvents. Salts sol water, methanol, ethanol. | | pka | pK1:9.72(＋1) (25°C) |
| | o-methylisourea Usage And Synthesis |
| Chemical Properties | O-Methylisourea is a colorless crystal with a temperature of 44-45°C. It can evaporate with ethanol and ether vapors and absorb moisture and carbon dioxide from the air. | | Uses | O-methylisourea can be used in the synthesis of heterocyclic compounds; it is a guanylation reagent and a selective alkylating agent. | | Application | Methyl Carbamimidate is preparation of Ph (3-methoxy-1,2,4-thiadiazol-5-yl)carbamate from O-methylisourea hydrochloride. | | Preparation | O-methylisourea hydrochloride is prepared in 69-80% yield by adding 1.15 equiv HCl(g) with ice cooling to cyanamide dissolved in excess anhydrous methanol. The free base is obtained from the salt using powdered KOH in a water-ether mixture or with sodium methoxide in methanol. The monoacetate salt can be prepared from the free base with 1 equiv of HOAc. Drying: vacuum desiccator over P2O5. | | storage | Salts are hygroscopic and should be stored in a desiccator even for brief periods. Heating O-methylisourea to decomposition can liberate toxic fumes of NOx. Use in a fume hood. |
| | o-methylisourea Preparation Products And Raw materials |
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