2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

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Products Intro:	Product Name:2-[[[4-(3-Methoxy Propoxy)-3-Methyl Pyridine-2-Yl]Methyl] Thio]-1H-Benzimidazole CAS:117977-21-6 Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg

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Products Intro:	Product Name:2-[[4-(3-Methoxypropoxy)-3-Methylpyridine-2-Yl] Methylthio]-1H-Benzimidazole CAS:117977-21-6

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Products Intro:	Product Name:2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole CAS:117977-21-6 Purity:0.99 Package:1kg 25kg 200 kilograms per barrel

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole manufacturers

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Basic information

Product Name:	2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
Synonyms:	2-[(4-METHOXYPROPOXY-3-METHYL-2-PYRIDINYL)-METHYLTHIO]-BENZIMIDAZOLE;2-[[(3-METHYL-4-(3-METHOXYPROPOXY)PYRIDINYL)METHYL]THIO]-1H-BENZIMIDAZOLE;Rabeprazole IMpurity F;2-(((4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole;rabeprazole sulphide;2-[[4-(3-Methoxypropoxy)-3-Methyl-2-pyridyl]Methylthio]benziMidazole;Rabeprazole Sulfide IMpurity;2-[[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methylsulfanyl]-1h-benziMidazole
CAS:	117977-21-6
MF:	C18H21N3O2S
MW:	343.45
EINECS:	601-502-8
Product Categories:	Heterocycle-Pyridine series;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;PHARMACEUTICAL INTERMEDIATES;(intermediate of raberprazole);Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Rabeprazole Sodium;Impurities & Metabolites;Rabeprazole
Mol File:	117977-21-6.mol

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Chemical Properties

Melting point	120.5-121.50C
Boiling point	546.4±60.0 °C(Predicted)
density	1.25±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	10.60±0.10(Predicted)
color	White to Off-White
InChI	InChI=1S/C18H21N3O2S/c1-13-16(19-9-8-17(13)23-11-5-10-22-2)12-24-18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChIKey	BSXAHDOWMOSVAP-UHFFFAOYSA-N
SMILES	C1(SCC2=NC=CC(OCCCOC)=C2C)NC2=CC=CC=C2N=1
CAS DataBase Reference	117977-21-6(CAS DataBase Reference)

Safety Information

HS Code

2933998350

MSDS Information

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Usage And Synthesis

Chemical Properties	Off-White Crystalline Powder
Uses	Rabeprazole Sulfide (Rabeprazole EP Impurity B) is a metabolite of Rabeprazole (R070500).
Synthesis	118175-10-3 134469-07-1 117977-21-6 General procedure for the synthesis of 2-[[[4-(3-methoxypropoxy)-3-methylpyrimidin-2-yl]methyl]thio]-1H-benzimidazole from 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine and 1H-benzo[d]imidazole-2-thiol: 100 g of 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine ( 473.35 mmol) in a 2L three-necked flask, 1 L of tetrahydrofuran was added as solvent, followed by 71.10 g of 1H-benzo[d]imidazole-2-thiol (473.35 mmol) and 136.58 g of triphenylphosphine (520.69 mmol). Stirring was turned on and the reaction temperature was controlled at 0 °C. Slowly 90.678 g of diethyl azodicarboxylate (520.69 mmol) was added dropwise. After the dropwise addition, the reaction was maintained for 5h to 10h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, the tetrahydrofuran was evaporated to dryness by rotary evaporator, and the resulting crude product was purified by recrystallization from methanol to give 130.0 g of the target product 2-[[[4-(3-methoxypropoxy)-3-methylpyrimidin-2-yl]methyl]thio]-1H-benzimidazole in 80% yield.
References	[1] Patent: CN106674198, 2017, A. Location in patent: Paragraph 0020-0021

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Tag:2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole(117977-21-6) Related Product Information

1-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]-2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole RaBeprazole Impurity H (S)-Rabeprazole Sodium Salt N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfone 1H-BENZIMIDAZOLE-2-SULFONIC ACID 4-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfone 4-Desmethoxypropoxyl-4-chloro Rabeprazole 4-Nitro-2,3-lutidine-N-oxide Rabeprazole IMpurity G Rebeprazole sodium Rabeprazole 4-[(1H-Benzimidazol-2-yl)oxy]-3-methyl-2-pyridinecarboxylic Acid Discontinued See: B203960 Rabeprazole Impurity 2 2-[(4-Chloro-3-Methyl-2-Pyridinyl-methyl)thio]-1H-Benzimidazole Rabeprazole Impurity 2 Rabeprazole Related CoMpound A Rabeprazole Impurity 8 RABEPRAZOLE N-OXIDE