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| | 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Basic information |
| Product Name: | 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID | | Synonyms: | 4-Oxopyrrolidine-2-carboxylic acid, N-BOC protected 97%;BOC- 4-OXOPYRROLIDINE-2-CARBOXYLIC ACID;(2S)-1-TERT-BUTYL HYDROGEN 4-OXOPYRROLIDINE-1,2-DICARBOXYLATE;4-OXOPYRROLIDINE-2-CARBOXYLIC ACID, N-BOC PROTECTED;4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID;1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid 95%;1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid | | CAS: | 876317-19-0 | | MF: | C10H15NO5 | | MW: | 229.23 | | EINECS: | | | Product Categories: | 876317-19-0 | | Mol File: | 876317-19-0.mol |  |
| | 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Chemical Properties |
| Melting point | 155 °C | | Boiling point | 390.8±42.0 °C(Predicted) | | density | 1.304±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 3.85±0.20(Predicted) | | form | solid | | color | Brown |
| | 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Usage And Synthesis |
| Uses | 1-[(tert-Butoxy)carbonyl]-4-oxopyrrolidine-2-carboxylic Acid may be useful in the preparation of pyridinylethynyldihydropyrroloquinazolinone derivatives and analogs for use as metabotropic glutamate receptor 5 modulators. | | Synthesis | General procedure for the synthesis of 1-tert-butyl-4-oxopyrrolidine-2-carboxylic acid from 1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid: 1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (178 g, 0.77 mol) was dissolved in dichloromethane (2.0 L), trichloroisocyanuric acid (178.89 g, 0.77 mol), followed by 2,2,6,6-tetramethylpiperidine oxide (6.05 g, 0.0385 mol). The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction was quenched with water and the insoluble material was removed by filtration. The aqueous phase was extracted several times with dichloromethane, all organic phases were combined and dried with anhydrous sodium sulfate. Finally, the organic phase was concentrated to dryness under vacuum to give 1-tert-butyl-4-oxopyrrolidine-2-carboxylic acid (180 g) in 100% yield. | | References | [1] Patent: CN105503891, 2016, A. Location in patent: Paragraph 0008; 0016 |
| | 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials |
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