| 中文名称 | 1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[(3R,4S)-3,4-dihydro-7-hydroxy-3-phenyl-2H-1-benzopyran-4-yl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-, rel- |
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| 中文同义词 | |
| 英文名称 | 1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[(3R,4S)-3,4-dihydro-7-hydroxy-3-phenyl-2H-1-benzopyran-4-yl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-, rel- |
| 英文同义词 | 1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[(3R,4S)-3,4-dihydro-7-hydroxy-3-phenyl-2H-1-benzopyran-4-yl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-, rel-;PROTAC ER Degrader-10;2-(2,6-dioxopiperidin-3-yl)-5-{4-[(1-{4-[(3R,4S)-7-hydroxy-3-phenyl-3,4-dihydro-2H-1-benzopyran-4-yl]phenyl}piperidin-4-yl)methyl]piperazin-1-yl}-2,3-dihydro-1H-isoindole-1,3-dione |
| CAS号 | 2504911-58-2 |
| 分子式 | C44H45N5O6 |
| 分子量 | 739.86 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2504911-58-2.mol |
| 结构式 | ![1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[(3R,4S)-3,4-dihydro-7-hydroxy-3-phenyl-2H-1-benzopyran-4-yl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-, rel- 结构式](CAS/20210305/GIF/2504911-58-2.gif) |
1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[(3R,4S)-3,4-dihydro-7-hydroxy-3-phenyl-2H-1-benzopyran-4-yl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-, rel- 性质
| 密度 | 1.332±0.06 g/cm3(Predicted) |
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| 酸度系数(pKa) | 9.91±0.60(Predicted) |
1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[(3R,4S)-3,4-dihydro-7-hydroxy-3-phenyl-2H-1-benzopyran-4-yl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-, rel- 用途与合成方法
PROTAC ER Degrader-10 是一种有效的 PROTAC ER 降解剂，可用于癌症研究。PROTAC ER Degrader-10 源自专利 WO2021133886，例 36。