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| | 5-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE Basic information |
| | 5-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE Chemical Properties |
| Boiling point | 82-86℃ | | density | 1.423±0.06 g/cm3(Predicted) | | refractive index | 1.4880 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | liquid | | color | Clear, colourless | | Sensitive | Air Sensitive |
| | 5-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-chloro-2-trifluoromethylbenzaldehyde from (5-chloro-2-trifluoromethylphenyl)methanol: (5-chloro-2-trifluoromethylphenyl)methanol (347 mg, 1.66 mmol) was dissolved in dichloromethane (10 mL). Pyridinium chlorochromate (717 mg, 3.32 mmol) was added to the solution and the reaction mixture was stirred for 2 hours at room temperature. After the reaction was completed, the reaction solution was diluted with ether and stirring was continued for 1 hour. Subsequently, the reaction mixture was filtered to remove insoluble impurities and the filtrate was concentrated to remove solvent. Finally, the crude product was purified by silica gel column chromatography using a hexane solution of 10% ethyl acetate as eluent to afford 5-chloro-2-trifluoromethylbenzaldehyde as a colorless oil (285 mg, 82% yield).1H NMR (400 MHz, MeOH-d4) δ 10.33 (s, 1H), 7.90 (s, 1H), 7.69 (d, 1H, J = 8.4 Hz), 7.54 (d, 1H, J = 8.4 Hz). | | References | [1] Patent: WO2006/44454, 2006, A1. Location in patent: Page/Page column 13-14 |
| | 5-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE Preparation Products And Raw materials |
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