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| | tert-Butyl 3-aminobenzylcarbamate Basic information |
| Product Name: | tert-Butyl 3-aminobenzylcarbamate | | Synonyms: | (3-Aminobenzyl)carbamic acid tert-butyl ester;tert-butyl N-[(3-aMinophenyl)Methyl]carbaMate;N-(3-aMinophenylMethyl)carbaMic acid t-butyl ester;3-(Aminomethyl)aniline, 3-BOC protected;tert-Butyl (3-aminobenzyl)carbamate, 3-{[(tert-Butoxycarbonyl)amino]methyl}aniline;3-Amino-N-(tert-butoxycarbonyl)benzylamine;tert-Butyl 3-aminobenzylcarbamate AldrichCPR;tert-Butyl 3-aminobenzylcarbamate | | CAS: | 147291-66-5 | | MF: | C12H18N2O2 | | MW: | 222.28 | | EINECS: | 200-110-4 | | Product Categories: | | | Mol File: | 147291-66-5.mol |  |
| | tert-Butyl 3-aminobenzylcarbamate Chemical Properties |
| Melting point | 48.0 to 56.0 °C | | Boiling point | 386.0±25.0 °C(Predicted) | | density | 1.095±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 12.31±0.46(Predicted) | | color | White to Light yellow |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | HS Code | 2924297099 |
| | tert-Butyl 3-aminobenzylcarbamate Usage And Synthesis |
| Synthesis | Step 2: Synthesis of tert-butyl 3-aminobenzylcarbamate (3); To a solution of tert-butyl 3-nitrobenzylcarbamate (2, 0.69 g, 2.73 mmol) in ethanol (20 mL) was added 10% Pd-C (50 mg), and the resulting mixture was stirred for 30 min at room temperature under hydrogen atmosphere. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and washed with ethanol. Ethanol was evaporated from the filtrate under reduced pressure to give tert-butyl 3-aminobenzylcarbamate (3, 0.6 g, 98%). NMR hydrogen spectrum (400 MHz, CDCl3): δ 7.22 (s, 1H), 7.10-7.00 (t, 1H), 6.70-6.60 (d, 1H), 6.60-6.50 (m, 1H), 4.20 (bs, 2H), 1.40 (s, 9H). | | References | [1] Patent: WO2011/140338, 2011, A1. Location in patent: Page/Page column 60-61
[2] Chemical Communications, 2014, vol. 50, # 97, p. 15305 - 15308
[3] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 19, p. 4189 - 4206
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 15, p. 2858 - 2871
[5] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 6, p. 883 - 886 |
| | tert-Butyl 3-aminobenzylcarbamate Preparation Products And Raw materials |
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