5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER
manufacturers
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| | 5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER
Basic information |
| Product Name: | 5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER
| | Synonyms: | Ethyl5-oxopyrrolidine-3-carboxylate;3-Pyrrolidinecarboxylic acid, 5-oxo-, ethyl ester;Ethyl 2-oxopyrrolidine-4-carboxylate;2-Oxo-pyrrolidine-4-carboxylic acid ethyl ester;Ethyl 2-oxopyrrolidine-4-carboxylate 95+%;5-oxo-3-pyrrolidinecarboxylic acid ethyl ester;Ethyl2-oxopyrrolidine-4-carboxylate,96%;Ethyl 5-oxo-3-pyrrolidinecarboxylate | | CAS: | 60298-18-2 | | MF: | C7H11NO3 | | MW: | 157.17 | | EINECS: | | | Product Categories: | | | Mol File: | 60298-18-2.mol |  |
| | 5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER
Chemical Properties |
| Melting point | 40-47℃ | | Boiling point | 312.7±35.0 °C(Predicted) | | density | 1.161±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | Solid | | pka | 15.39±0.40(Predicted) | | color | Pale brown to dark brown |
| WGK Germany | 1 | | HS Code | 2933998090 |
| | 5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER
Usage And Synthesis |
| Synthesis | GENERAL METHOD: To a solution of ethyl 3-oxocyclobutanecarboxylate (100 mg, 0.45 mmol) in dichloromethane (3.8 mL) was slowly added hydrogen chloride (2 M, 1.4 mL) at room temperature. Subsequently, O- homotrimethylbenzenesulfonylhydroxylamine (2.00 equiv, 2.0000) was added and the reaction mixture was stirred for 3 hours. After completion of the reaction, saturated NaHCO3 solution was added for neutralization and the organic layer was extracted with dichloromethane. The organic layers were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by rapid chromatography on silica gel to afford ethyl 5-oxopyrrolidine-3-carboxylate (87 mg, 0.802 mmol, 80% yield) as a white solid. | | References | [1] Tetrahedron Letters, 2018, vol. 59, # 20, p. 1896 - 1901 |
| | 5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER
Preparation Products And Raw materials |
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