| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532; 18210857532 |
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jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Apigenin-d5 (Major)
CAS:263711-74-6
Package:10Mg,1Mg
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| | Apigenin-D5 Basic information |
| Product Name: | Apigenin-D5 | | Synonyms: | Apigenin-D5;[3,6,8,35d5]-Apigenin;4',5,7-Trihydroxyflavone-d5;5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5;Pelargidenon 1449-d5;Apigenin-d5 (Major);3,6,8-trideuterio-2-(3,5-dideuterio-4-hydroxyphenyl)-5,7-dihydroxychromen-4-one;4H-1-Benzopyran-4-one-3,6,8-d3, 5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)- | | CAS: | 263711-74-6 | | MF: | C15H5D5O5 | | MW: | 0 | | EINECS: | | | Product Categories: | Isotope Labelled Compounds;Inhibitors;Isotope Labeled Compounds | | Mol File: | 263711-74-6.mol |  |
| | Apigenin-D5 Chemical Properties |
| Melting point | 345-350°C | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly) | | form | Solid | | color | Pale Yellow to Yellow |
| | Apigenin-D5 Usage And Synthesis |
| Description | Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1. | | Chemical Properties | Pale Yellow Crystalline Solid | | Uses | The labelled aglucon of apiin and of apigenin-7-glucoside | | in vivo | Apigenin (4',5,7-Trihydroxyflavone), a natural flavonoid, possesses a broad spectrum of biological properties, including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects. Apigenin (125 mg/kg and 250 mg/kg) alleviates Adriamycin (ADR) (24 mg/kg)-induced myocardial injury. Apigenin inhibits serum aspartate amino transferase (AST) release. Apigenin reduces serum lactate dehydrogenase (LDH) release. Apigenin reduces serum creatine kinase (CK) contents[4]. | | References | [1] MASATERU YAMADA. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 21: 7736-7741. DOI: 10.1073/pnas.0409818102
[2] JIAN SHEN. Phosphorylation by the Protein Kinase CK2 Promotes Calpain-Mediated Degradation of IκBα1[J]. The Journal of Immunology, 2001, 25 1: 4919-4925. DOI: 10.4049/jimmunol.167.9.4919
[3] GIUSEPPINA MATTACE RASO. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1[J]. Life sciences, 2001, 68 8: Pages 921-931. DOI: 10.1016/s0024-3205(00)00999-1 |
| | Apigenin-D5 Preparation Products And Raw materials |
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