| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
|
| | (S)-AL 8810 Basic information |
| Product Name: | (S)-AL 8810 | | Synonyms: | (S)-AL 8810;WTYSXBKKVNOOIX-KSKLXAOMSA-N;9ALPHA,15S-DIHYDROXY-11BETA-FLUORO-15-(2,3-DIHYDRO-1H-INDEN-2-YL)-16,17,18, 19,20-PENTANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3S)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)- | | CAS: | 1224444-55-6 | | MF: | C24H31FO4 | | MW: | 402.5 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | (S)-AL 8810 Chemical Properties |
| Boiling point | 594.6±50.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: miscible; PBS (pH 7.2): 0.5 mg/ml | | form | A crystalline solid | | pka | 4.76±0.10(Predicted) |
| | (S)-AL 8810 Usage And Synthesis |
| Description | AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor. (S)-AL 8810 is the C-15 epimer of AL 8810, having the inverse, (S), or “natural” configuration at C-15 relative to AL 8810, which is 15-(R). The pharmacology of (S)-AL 8810 has not been published. | | Uses | (S)-AL 8810 is an 11β-fluoro analog of PGF2α that acts as a potent and selective antagonist at the FP receptor. (S)-AL 8810 is the C-15 epimer of AL 8810, having the
inverse, (S), or "natural" configuration at C-15 relative to AL 8810, which is 15-(R)[1]. | | Definition | ChEBI: 5-heptenoic acid, 7-[(1r,2r,3s,5s)-2-[(1e,3s)-3-(2,3-dihydro-1h-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5z)- is a long-chain fatty acid. | | References | [1] Griffin BW, Klimko P, Crider JY, Sharif NA. AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84. PMID:10454504 |
| | (S)-AL 8810 Preparation Products And Raw materials |
|