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| | Ditercalinium Basic information |
| Product Name: | Ditercalinium | | Synonyms: | Ditercalinium;2,2'-[4,4'-Bipiperidine-1,1'-diylbis(ethylene)]bis[10-methoxy-7H-pyrido[4,3-c]carbazol-2-ium];NSC-366241;NSC-335153 | | CAS: | 74517-42-3 | | MF: | C46H50Cl2N6O2 | | MW: | 789.8342 | | EINECS: | | | Product Categories: | | | Mol File: | 74517-42-3.mol |  |
| | Ditercalinium Chemical Properties |
| form | Solid | | color | Light yellow to yellow |
| | Ditercalinium Usage And Synthesis |
| Uses | Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein[1][2]. | | References | [1] Okamaoto M, et al. Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication. Curr Genet. 2003 Aug;43(5):364-70. DOI:10.1007/s00294-003-0393-4
[2] Sandhya Rai, et al. Ditercalinium chloride: A potential inhibitor targeting recurrent in frame COMMD10-AP3S1 fusions in CRCs. Gene Reports. 2023, 30:101739. |
| | Ditercalinium Preparation Products And Raw materials |
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