Safrazine manufacturers
- Safrazine
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- $1980.00
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2026-05-11
- CAS:33419-68-0
- Purity:
- Supply Ability: 10g
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| | Safrazine Basic information |
| Product Name: | Safrazine | | Synonyms: | Safrazine;1-[3-(1,3-Benzodioxol-5-yl)-1-methylpropyl]hydrazine;Safrasine;Saphrazine;4-(1,3-benzodioxol-5-yl)butan-2-ylhydrazine | | CAS: | 33419-68-0 | | MF: | C11H16N2O2 | | MW: | 208.25694 | | EINECS: | | | Product Categories: | | | Mol File: | 33419-68-0.mol |  |
| | Safrazine Chemical Properties |
| Boiling point | 347.46°C (rough estimate) | | density | 1.1123 (rough estimate) | | refractive index | 1.5000 (estimate) |
| | Safrazine Usage And Synthesis |
| Uses | Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression[1]. | | in vivo | Safrazine (oral; 3, 10, 30 mg/kg) causes the increases contents of monoamine lasted for at least 24 h[1].
Safrazine strongly inhibits both 5-HT and PEA deaminations, but shows no selectivity toward the substrate used[1]. | Animal Model: | Male ddY mice[1] | | Dosage: | 3, 10, 30 mg/kg | | Administration: | Oral | | Result: | Inhibited significantly both 5-HT and PEA deaminations at only 3 mg/kg by 77% and 71%, respectively.
Completely reduced both deaminations at 10 and 30 mg/kg and not observed specificity toward substrates.
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| | References | [1] T Yokoyama, et al. Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain. J Pharm Pharmacol. 1989 Jan;41(1):32-6. DOI:10.1111/j.2042-7158.1989.tb06324.x |
| | Safrazine Preparation Products And Raw materials |
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