1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-

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1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Basic information
Product Name:1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-
Synonyms:1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-;GSK3-IN-10
CAS:844441-56-1
MF:C17H18F2N4O3
MW:364.35
EINECS:
Product Categories:
Mol File:844441-56-1.mol
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Structure
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Chemical Properties
Boiling point 539.9±50.0 °C(Predicted)
density 1.389±0.06 g/cm3(Predicted)
solubility DMSO: 2 mg/mL, clear
pka10.80±0.70(Predicted)
form powder
color white to beige
SMILESO=C(NCC1CCOCC1)C2=NNC=C2NC(C3=C(C=CC=C3F)F)=O
Safety Information
MSDS Information
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Usage And Synthesis
UsesGSK3-IN-10 (Compound 4) is a multi-target inhibitor, that mainly targets GSK3α and GSK3β with IC50 of 1.0 nM and 2.0 nM. GSK3-IN-10 inhibits the activation of β-catenin, promotes the neuronal survival, and exhibits a protective effect against endoplasmic reticulum stress[1].
IC 50GSK-3α: 1.0 nM (IC50); GSK-3β: 2.0 nM (IC50); DYRK1B: 47 nM (IC50); DYRK1A: 170 nM (IC50); ICK: 520 nM (IC50); CLK1: 620 nM (IC50); CLK4: 760 nM (IC50); DYRK2: 800 nM (IC50); CLK2: 800 nM (IC50); CDKL5: 840 nM (IC50); JNK3: 2900 nM (IC50); CDK4: 3800 nM (IC50)
References[1] Ong HW, et al., Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS Chem Neurosci. 2023 May 3;14(9):1672-1685. DOI:10.1021/acschemneuro.3c00135
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Preparation Products And Raw materials
Tag:1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-(844441-56-1) Related Product Information
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