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| 2,6-Piperidinedione, 3-[6-[[1-[1-[(1-methylcyclobutyl)methyl]-4-piperidinyl]-1H-pyrazol-4-yl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]- Basic information |
| 2,6-Piperidinedione, 3-[6-[[1-[1-[(1-methylcyclobutyl)methyl]-4-piperidinyl]-1H-pyrazol-4-yl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]- Chemical Properties |
Boiling point | 776.5±60.0 °C(Predicted) | density | 1.42±0.1 g/cm3(Predicted) | pka | 10.70±0.40(Predicted) |
| 2,6-Piperidinedione, 3-[6-[[1-[1-[(1-methylcyclobutyl)methyl]-4-piperidinyl]-1H-pyrazol-4-yl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]- Usage And Synthesis |
Uses | E3 ligase Ligand 21 (compound 2) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway[1]. | IC 50 | Cereblon | References | [1] Gesine Kerstin VEITS, et al. Cereblon binders for the degradation of ikaros. WO2019191112A1. |
| 2,6-Piperidinedione, 3-[6-[[1-[1-[(1-methylcyclobutyl)methyl]-4-piperidinyl]-1H-pyrazol-4-yl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]- Preparation Products And Raw materials |
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