- 4-Fluoro-m-anisaldehyde
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- $100.00 / 1kg
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2024-04-23
- CAS:128495-46-5
- Min. Order: 1kg
- Purity: 99.93%
- Supply Ability: 1000kg per week
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| | 4-FLUORO-3-METHOXYBENZALDEHYDE Basic information |
| | 4-FLUORO-3-METHOXYBENZALDEHYDE Chemical Properties |
| Melting point | 58-62 °C(lit.) | | Boiling point | 93 °C(Press: 4.5 Torr) | | density | 1.192±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | color | White to Light yellow | | Sensitive | Air Sensitive | | BRN | 5178063 | | InChI | InChI=1S/C8H7FO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-5H,1H3 | | InChIKey | NALVGTOMKSKFFV-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(F)C(OC)=C1 | | CAS DataBase Reference | 128495-46-5(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-37/38-41-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 2 | | HazardClass | IRRITANT | | HS Code | 29124990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 4-FLUORO-3-METHOXYBENZALDEHYDE Usage And Synthesis |
| Chemical Properties | White to yellow to tan powder or crystal or crystalline powder | | Uses | | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 33, p. 2408, 1990 DOI: 10.1021/jm00171a014 | | Synthesis | General procedure for the synthesis of 3-methoxy-4-fluorobenzaldehyde from 3-methoxy-4-fluorobenzyl alcohol: (4-fluoro-3-methoxyphenyl)methanol (5.00 g, 0.03 mol) was mixed with manganese dioxide (33.4 g, 0.38 mol) in dichloromethane (100 mL) under nitrogen protection, and the reaction was stirred for 16 hr under mild reflux conditions. Upon completion of the reaction, the reaction mixture was cooled to room temperature, filtered through Arbacel, and the filtrate was concentrated in vacuum to afford 3-methoxy-4-fluorobenzaldehyde (4.18 g, 0.027 mol, 85% yield) as a white solid. The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 3.96 (s, 3H), 7.23 (d, 1H), 7.43 (m, 1H), 7.50 (d, 1H), 9.91 (s, 1H). The melting point is 61-63°C. Elemental analysis results: measured value C, 62.18; H, 4.54%. Theoretical value (C8H7FO2): C, 62.34; H, 4.58%. | | References | [1] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2408 - 2412
[2] Patent: WO2004/52372, 2004, A1. Location in patent: Page 72
[3] Patent: WO2008/87512, 2008, A1. Location in patent: Page/Page column 43
[4] Patent: EP2862571, 2015, A1. Location in patent: Paragraph 0164; 0165
[5] Patent: US2015/166559, 2015, A1. Location in patent: Paragraph 0220; 0221 |
| | 4-FLUORO-3-METHOXYBENZALDEHYDE Preparation Products And Raw materials |
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