Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-

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Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Suppliers list
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Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Basic information
Product Name:Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-
Synonyms:DB0614;N-(3-(2-((4-(4-(5-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)piperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide;DB0614/2769753-47-9;Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-;N-[3-[2-[[4-[4-[5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]methanesulfonamide
CAS:2769753-47-9
MF:C41H42N8O7S2
MW:822.96
EINECS:
Product Categories:
Mol File:2769753-47-9.mol
Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Structure
Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Chemical Properties
density 1.437±0.06 g/cm3(Predicted)
pka7.85±0.10(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Usage And Synthesis
UsesDB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1][2].(Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070))
IC 50CDK6; CDK16/Cyclin Y; ULK1; Aurora Kinase; SIK2; LIMK2
References[1] SeongShick Ryu, et al. Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9[J]. Current Research in Chemical Biology. 2021. 1:100008.
[2] William Thomas Darlow, et al. Discovery of NEK9 and Aurora A PROTACs Using a Proteomics-Based Screening Approach. The Institute of Cancer Research. 2022.
[3] GRAY, Nathanael S. Compounds for targeted protein degradation of kinases. WO2022093742. 2022/093742
Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- Preparation Products And Raw materials
Tag:Methanesulfonamide, N-[3-[2-[[4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1-piperazinyl]phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-(2769753-47-9) Related Product Information
CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) Erastin CDK2 Protein, HUMAN (HIS) PCTAIRE1 Protein, Human (sf9, GST) CDK9 Protein, Human (sf9, GST)