| Company Name: |
Pure Chemistry Scientific Inc.
|
| Tel: |
001-857-928-2050 or 1-888-588-9418 |
| Email: |
sales@chemreagents.com |
| Products Intro: |
Product Name:2-Iodo-6-Methoxypyrazine
CAS:58139-03-0
Purity:0% Package:1g;5g
|
|
| | 2-IODO-6-METHOXYPYRAZINE Basic information |
| | 2-IODO-6-METHOXYPYRAZINE Chemical Properties |
| Melting point | 36.6-38.1°C | | Fp | >110℃ | | form | solid | | InChI | 1S/C5H5IN2O/c1-9-5-3-7-2-4(6)8-5/h2-3H,1H3 | | InChIKey | NSZWVUZALRZRLQ-UHFFFAOYSA-N | | SMILES | COc1cncc(I)n1 |
| Hazard Codes | Xn | | Risk Statements | 10-22-37/38-41 | | Safety Statements | 16-26-37 | | WGK Germany | 3 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2-IODO-6-METHOXYPYRAZINE Usage And Synthesis |
| Synthesis | Phase 2: Preparation of 2-iodo-6-methoxypyrazine
2,6-Diiodopyrazine (5.0 g, 15 mmol) was added to a pre-prepared methanolic solution of sodium methanolate (prepared by reacting sodium metal (0.35 g, 15 mmol) with methanol (40 mL)). The reaction mixture was heated to reflux temperature and maintained for 1 hour. After completion of the reaction, it was cooled to room temperature and the reaction solution was diluted with water (200 mL) and subsequently extracted with diethyl ether (3 × 100 mL). The organic phases were combined, washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford 2-iodo-6-methoxypyrazine as a white solid (3.5 g, 100% yield). Melting point: 35.7-37.2 °C. NMR hydrogen spectrum (90 MHz, CDCl3): δ 8.40 (1H, single peak), 8.16 (1H, single peak), 3.98 (3H, single peak). Mass spectrum (m/z): 236 (M+), 127, 109 (100%). | | References | [1] Patent: US4975112, 1990, A
[2] Patent: US5260293, 1993, A |
| | 2-IODO-6-METHOXYPYRAZINE Preparation Products And Raw materials |
|