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| | Benzoic acid, 3-(2-quinolinylmethoxy)-, methyl ester Basic information |
| | Benzoic acid, 3-(2-quinolinylmethoxy)-, methyl ester Chemical Properties |
| Boiling point | 448.2±25.0 °C(Predicted) | | density | 1.225±0.06 g/cm3(Predicted) | | solubility | DMF: insol; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol | | form | A crystalline solid | | pka | 3.69±0.48(Predicted) |
| | Benzoic acid, 3-(2-quinolinylmethoxy)-, methyl ester Usage And Synthesis |
| Description | CAY10788 is an antagonist of CysLT1 receptor. | | Uses | CysLT1 receptor antagonist-1 (Compound 4) is an antagonist for cysteinyl leukotriene receptor 1 (CysLT1R) with an IC50 of 3.9 μM. CysLT1 receptor antagonist-1 exhibits weak agonist activity against G-protein-coupled bile acid receptor 1 (GPBAR1) with an efficact of 23% at 10 μM. CysLT1 receptor antagonist-1 can be used for asthma and allergic diseases researchs[1]. | | IC 50 | CysLT1: 3.9 μM (IC50) | | References | [1] Fiorillo B, et al., Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529. DOI:10.1021/acs.jmedchem.1c01078 |
| | Benzoic acid, 3-(2-quinolinylmethoxy)-, methyl ester Preparation Products And Raw materials |
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