|
|
| | 5-Phenylthiophene-2-carboxylic acid Basic information | | Uses |
| | 5-Phenylthiophene-2-carboxylic acid Chemical Properties |
| Melting point | 186-190°C | | Boiling point | 393.6±30.0 °C(Predicted) | | density | 1.303±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 3.52±0.10(Predicted) | | form | powder to crystal | | color | White to Orange to Green | | λmax | 310nm(EtOH)(lit.) | | CAS DataBase Reference | 19163-24-7(CAS DataBase Reference) |
| | 5-Phenylthiophene-2-carboxylic acid Usage And Synthesis |
| Uses | Thiophene derivatives are widely used in the synthesis of pesticides, pharmaceuticals, chemical reagents, dyes, and polymer auxiliaries. 5-Phenylen-2-carboxylic acid has extensive applications in organic synthesis. | | Definition | ChEBI: 5-Phenylthiophene-2-carboxylic acid is a thiophenecarboxylic acid. | | Synthesis | GENERAL STEPS: To a mixed solution of methanol (5 mL) and tetrahydrofuran (5 mL) of 2-methoxycarbonyl-5-phenylthiophene (437 mg) was added 1 N aqueous sodium hydroxide (3 mL), and the reaction was stirred for 2 hours at room temperature. After completion of the reaction, 1 N hydrochloric acid (5 mL) was slowly added to the reaction mixture for acidification. The precipitated solid was collected by filtration and washed with a small amount of cold water and dried under vacuum to give 5-phenylthiophene-2-carboxylic acid (397 mg, 97.1% yield). The product was confirmed by NMR hydrogen spectrum (DMSO-d6, δ): 7.3-7.5 (3H, m), 7.58 (1H, d, J = 3.9 Hz), 7.6-7.8 (3H, m), 13.15 (1H, wide s). Electrospray mass spectrometry (ESI-MS) showed m/z: 203 ([M-H]-). | | References | [1] Patent: US6770667, 2004, B1. Location in patent: Page column 11
[2] ChemMedChem, 2011, vol. 6, # 2, p. 362 - 377
[3] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5536 - 5548 |
| | 5-Phenylthiophene-2-carboxylic acid Preparation Products And Raw materials |
|