6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one
| 中文名称 | 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one |
|---|---|
| 中文同义词 | 化合物 R 115777 |
| 英文名称 | 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one |
| 英文同义词 | 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one;2(1H)-Quinolinone, 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl- |
| CAS号 | 192185-68-5 |
| 分子式 | C27H22Cl2N4O |
| 分子量 | 489.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 192185-68-5.mol |
| 结构式 | ![6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one 结构式](CAS/GIF/192185-68-5.gif) |
6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one 性质
| 熔点 | 214 °C(Solv: acetonitrile (75-05-8); dichloromethane (75-09-2); methanol (67-56-1)) |
|---|---|
| 沸点 | 681.7±55.0 °C(Predicted) |
| 密度 | 1.33±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 7.20±0.10(Predicted) |
6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one 用途与合成方法
(Rac)-Tipifarnib ((Rac)-IND 58359；(Rac)-R115777) 是一种强效的法尼基蛋白转移酶抑制剂，专门靶向 Ras 蛋白的前尾化过程。(Rac)-Tipifarnib 在小鼠口服后显示出显著的体内抗肿瘤效果。