2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)-

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2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:CDK1/2/4-IN-1
CAS:2414633-49-9
Package:50mg;1980USD|100mg;2500USD|25mg;1520USD
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:CDK1/2/4-IN-1
CAS:2414633-49-9
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600

2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- manufacturers

  • CDK1/2/4-IN-1
  • CDK1/2/4-IN-1 pictures
  • $1980.00 / 50mg
  • 2026-04-20
  • CAS:2414633-49-9
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- Basic information
Product Name:2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)-
Synonyms:2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)-;CDK1/2/4-IN-1
CAS:2414633-49-9
MF:C15H16N2O2S
MW:288.36
EINECS:
Product Categories:
Mol File:2414633-49-9.mol
2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- Structure
2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- Chemical Properties
Boiling point 480.4±55.0 °C(Predicted)
density 1.241±0.06 g/cm3(Predicted)
pka3.01±0.10(Predicted)
Safety Information
MSDS Information
2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- Usage And Synthesis
UsesCDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
IC 50CDK2: 0.78 (IC50); CDK4: 0.87 (IC50); CDK1: 1.47 (IC50); Caspase 3; Bax; Bcl-2
References[1] Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761. DOI:10.1016/j.bioorg.2020.103761
2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- Preparation Products And Raw materials
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