| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:FLT3/ITD-IN-2
CAS:2489446-59-3
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
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Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-(4-morpholinyl)-2-(trifluoromethyl)phenyl]-5-[(3R)-3-piperidinylamino]- manufacturers
- FLT3/ITD-IN-2
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- $2500.00 / 100mg
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2025-10-27
- CAS:2489446-59-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-(4-morpholinyl)-2-(trifluoromethyl)phenyl]-5-[(3R)-3-piperidinylamino]- Basic information |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-(4-morpholinyl)-2-(trifluoromethyl)phenyl]-5-[(3R)-3-piperidinylamino]- Chemical Properties |
| density | 1.51±0.1 g/cm3(Predicted) | | pka | 10.86±0.70(Predicted) |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-(4-morpholinyl)-2-(trifluoromethyl)phenyl]-5-[(3R)-3-piperidinylamino]- Usage And Synthesis |
| Uses | FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1]. | | References | [1] Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422. DOI:10.1016/j.bmc.2021.116422 |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-(4-morpholinyl)-2-(trifluoromethyl)phenyl]-5-[(3R)-3-piperidinylamino]- Preparation Products And Raw materials |
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