1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl-

Request For Quotation
1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- Suppliers list
Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com 18017580634
Email: hanfangpharma@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- manufacturers
1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- Basic information
Product Name:1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl-
Synonyms:1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl-;Topoisomerase I inhibitor 7
CAS:2408639-81-4
MF:C22H19N3O5
MW:405.4
EINECS:
Product Categories:
Mol File:2408639-81-4.mol
1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- Structure
1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- Chemical Properties
Boiling point 737.2±60.0 °C(Predicted)
density 1.561±0.06 g/cm3(Predicted)
pka8.33±0.20(Predicted)
Safety Information
MSDS Information
1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- Usage And Synthesis
UsesTopoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones[1].
References[1] Tikhomirov AS, et al. Amides of pyrrole- and thiophene-fused anthraquinone derivatives: A role of the heterocyclic core in antitumor properties. Eur J Med Chem. 2020 Aug 1;199:112294. DOI:10.1016/j.ejmech.2020.112294
1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- Preparation Products And Raw materials
Tag:1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl-(2408639-81-4) Related Product Information
Doxorubicin hydrochloride Cholesteryl hemisuccinate Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]- Mitoxantrone BETA-LAPACHONE Datopotamab deruxtecan