1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide

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1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide manufacturers
1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Basic information
Product Name:1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide
Synonyms:ATX inhibitor 21;1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide
CAS:2691936-89-5
MF:C26H25F2N5O2S
MW:509.57
EINECS:
Product Categories:
Mol File:2691936-89-5.mol
1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Structure
1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Chemical Properties
density 1.38±0.1 g/cm3(Predicted)
pka11.32±0.46(Predicted)
Safety Information
MSDS Information
1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Usage And Synthesis
UsesATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC50 of 3490 nM[1].
IC 50Autotaxin: 3490 ± 170 nM (IC50)
References[1] Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115795. DOI:10.1016/j.bmc.2020.115795
1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Preparation Products And Raw materials
Tag:1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide(2691936-89-5) Related Product Information
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