2-(PIPERAZIN-1-YL)-ACETIC ACID H2O manufacturers
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| | 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O Basic information | | Application |
| Product Name: | 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O | | Synonyms: | 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O;2-(PIPERAZIN-1-YL)ACETIC ACID HYDRATE;AKOS BB-5495;IFLAB-BB F1929-1681;PIPERAZIN-1-YL-ACETIC ACID;TIMTEC-BB SBB010118;1-PIPERAZINYLACETIC ACID;2-(1-piperazinyl)acetic acid hydrate | | CAS: | 37478-58-3 | | MF: | C6H12N2O2 | | MW: | 144.17 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 37478-58-3.mol |  |
| | 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O Chemical Properties |
| Melting point | >220°C | | Boiling point | 292.6±25.0 °C(Predicted) | | density | 1.146±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 1.85±0.10(Predicted) | | Appearance | White to off-white Solid | | CAS DataBase Reference | 37478-58-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2933599590 |
| | 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O Usage And Synthesis |
| Application | 2-(piperazin-1-yl)acetic acid hydrate can be used as a pharmaceutical synthesis intermediate. | | Synthesis | To a solution of tert-butyl piperazine-1-carboxylate (2.0 g, 10.74 mmol) in THF (20 mL) was added Et3N (2.17 g, 21.48 mmol) and tert-butyl bromoacetate (2.09 g, 10.74 mmol). The resulting mixture was stirred at room temperature for 12 hours and then partitioned between ethyl acetate (200 mL) and water (100 mL). The organic layer was separated and washed with brine (100 mL), then dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography (eluent: PE/EA = 5/1, v:v) to afford tert-butyl 4-(2-tert-butoxy-2-oxo-ethyl)piperazine-1-carboxylate (2.5 g) as a white solid. A mixture of tert-butyl 4-(2-tert-butoxy-2-oxo-ethyl)piperazine-1-carboxylate (1.0 g, 3.3 mmol) and MeOH solution of HCl (1.0 M, 15 mL) was stirred at room temperature for 12 hours. The formed mixture was concentrated in vacuum. The residue was dissolved in MeOH (10 mL) and then treated with alkali resin and filtered. The filtrate was concentrated in vacuum to give 2-(piperazin-1-yl)acetic acid hydrate (350 mg) as a white solid. |
| | 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O Preparation Products And Raw materials |
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