- Methyldopa hydrate
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- $29.00 / 500mg
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2025-09-29
- CAS:41372-08-1
- Min. Order:
- Purity: 99.67%
- Supply Ability: 10g
- L-Methyldopa
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- $0.00 / 1Kg/Bag
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2025-09-29
- CAS:41372-08-1
- Min. Order: 1KG
- Purity: 98%-102%;USP
- Supply Ability: 100KGS
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| | alpha-Methyldopa sesquihydrate Basic information |
| | alpha-Methyldopa sesquihydrate Chemical Properties |
| Melting point | >300 °C(lit.) | | storage temp. | 2-8°C | | solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids. | | form | Solid | | color | White to Off-White | | Optical Rotation | [α]25/D 13°, c = 1 in H2O | | Water Solubility | 0.1-1 g/100 mL at 23 ºC | | Sensitive | Air & Light Sensitive | | Merck | 13,6080 | | BRN | 2417244 | | Stability: | Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere. | | InChI | InChI=1/C10H13NO4.H2O/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6;/h2-4,12-13H,5,11H2,1H3,(H,14,15);1H2/t10-;/s3 | | InChIKey | XDJUBZFLFDODNF-MEQOOBBNNA-N | | SMILES | [C@@](N)(C)(CC1C=CC(O)=C(O)C=1)C(=O)O.O |&1:0,r| | | CAS DataBase Reference | 41372-08-1(CAS DataBase Reference) |
| | alpha-Methyldopa sesquihydrate Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I. | | Uses | Antihypertensive agent. | | reaction suitability | reaction type: solution phase peptide synthesis | | Biological Activity | l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. | | Purification Methods | Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.] |
| | alpha-Methyldopa sesquihydrate Preparation Products And Raw materials |
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