二甲基 4-(3,4-二甲氧苯基)-1-羟基-5,6,7-三甲氧基萘-2,3-二甲酸基酯
| 中文名称 | 二甲基 4-(3,4-二甲氧苯基)-1-羟基-5,6,7-三甲氧基萘-2,3-二甲酸基酯 |
|---|---|
| 中文同义词 | 二甲基 4-(3,4-二甲氧苯基)-1-羟基-5,6,7-三甲氧基萘-2,3-二甲酸基酯;化合物 T13910;化合物 TA-7552 |
| 英文名称 | TA 7552 |
| 英文同义词 | TA 7552;4-(3,4-DIMETHOXY-PHENYL)-1-HYDROXY-5,6,7-TRIMETHOXY-NAPHTHALENE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER;2,3-Naphthalenedicarboxylic acid, 4-(3,4-dimethoxyphenyl)-1-hydroxy-5,6,7-trimethoxy-, 2,3-dimethyl ester;TA7552,TA 7552 |
| CAS号 | 104756-72-1 |
| 分子式 | C25H26O10 |
| 分子量 | 486.47 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 104756-72-1.mol |
| 结构式 |  |
二甲基 4-(3,4-二甲氧苯基)-1-羟基-5,6,7-三甲氧基萘-2,3-二甲酸基酯 性质
| 储存条件 | Store at -20°C |
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| 溶解度 | 溶于二甲基亚砜 |
TA-7552 是一种有效的胆固醇降低剂。
TA-7552 is a potent cholesterol-lowering agent. When TA-7552 is mixed with unsupplemented CLEA CE-2 powder in a concentration of 0.05% and administered to rats for 7 days, TA-7552 does not reduce the normal level of serum cholesterol. The hypocholesterolemic effect of TA-7552 is apparent at the lowest concentration (0.01%) of the drug in the diet, corresponding to a daily dose of ~10 mg/kg body weight, and maximal at the highest concentration of 0.2% TA-7552, lowering serum total cholesterol by 72% while elevating serum HDL cholesterol by 88%. TA-7552 also dose dependently suppresses this rise of hepatic cholesterol, and its lowering rate at the maximal dose is 90%.