L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine

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L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine Suppliers list
Company Name: Changsha MOL Changes Biotechnology Co., Ltd.
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Products Intro: Product Name:MK2-IN-5
CAS:474713-20-7
Purity:99% Package:5mg;10mg;100mg;1g;10g;100g
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CAS:474713-20-7
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Products Intro: Product Name:MK2-IN-5
CAS:474713-20-7
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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Products Intro: Product Name:MK2-IN-5
CAS:474713-20-7
Purity:98%HPLC Package:1mg;10mg;100mg
L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine Basic information
Product Name:L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine
Synonyms:L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine;MK2-IN-5
CAS:474713-20-7
MF:C61H113N21O16
MW:1396.68
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Mol File:474713-20-7.mol
L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine Structure
L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine Chemical Properties
density 1.40±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka3.43±0.10(Predicted)
SequenceLys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala
Safety Information
MSDS Information
L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine Usage And Synthesis
UsesMK2-IN-5 is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation[1][2][3].
in vivo

MK2-IN-5 (2 mg/kg Intraperitoneal injection, single dose) decreased HSP25 phosphorylation in ventilator-associated lung injury model[2].

Animal Model:ventilator-associated lung injury model[2]
Dosage:2 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Decreased HSP25 phosphorylation.
IC 50ERK1; ERK2
References[1] Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480. DOI:10.2174/138161209788682299
[2] Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600. DOI:10.1371/journal.pone.0004600
[3] Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539. DOI:10.1016/j.bbrc.2009.03.056
L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine Preparation Products And Raw materials
Tag:L-Lysyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-L-alanine(474713-20-7) Related Product Information