ICI 153110
| 中文名称 | ICI 153110 |
|---|---|
| 中文同义词 | 化合物 T11609;化合物 ICI 153110 |
| 英文名称 | ICI 153110 |
| 英文同义词 | ICI 153110;4,5-Dihydro-6-[(E)-2-(4-pyridinyl)ethenyl]-2H-pyridazin-3-one;3(2H)-Pyridazinone, 4,5-dihydro-6-[(1E)-2-(4-pyridinyl)ethenyl]-;(E)-4,5-Dihydro-6-(2-(4-pyridinyl)ethenyl)-3(2H)-pyridazinone |
| CAS号 | 87164-90-7 |
| 分子式 | C11H11N3O |
| 分子量 | 201.22 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 87164-90-7.mol |
| 结构式 |  |
ICI 153110 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
Phosphodiesterase
ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. Fourteen animals have died as a direct or indirect consequence of ICI 153110 administration in the high-dose main test and reversibility groups. In the female rat dosed at 10 mg/kg/day ICI 153110 a mild focal arteritis is characterized by a predominantly and diffusely adventitial infiltration of mixed cells and early formation of fibrous tissue. The two rats dosed at 250 mg/kg/day ICI 153110 die prematurely from intratracheal intubation of dosing solution. Arteries from two further animals (dosed at 5 and 250 mg/kg/day ICI 153110) show minimal focal arteritis with medial necrosis, and medial and adventitial inflammation.