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| | NVS MLLT-1 Basic information |
| Product Name: | NVS MLLT-1 | | Synonyms: | NVS MLLT-1;6-Isoquinolinecarboxamide, N-[2-[[(2S)-2-methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]- | | CAS: | 2561471-13-2 | | MF: | C23H23N5O | | MW: | 385.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2561471-13-2.mol |  |
| | NVS MLLT-1 Chemical Properties |
| Boiling point | 586.910±35.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.329±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | form | powder | | pka | 11.028±0.10(predicted) | | color | white to beige |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | NVS MLLT-1 Usage And Synthesis |
| Uses | NVS MLLT-1 (compound 3) is a potent and selective MLLT1 inhibitor with Kd values of 0.18 μM, 0.24 μM, and 0.22 μM for wild-type, T1 mutants, and T3 mutants, respectively[1][2]. | | Biological Activity | NVP-MLLT-1 is a potent and selective inhibitor against YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). | | References | [1] Ni X, et al. Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. ACS Chem Biol. 2021 Apr 16;16(4):571-578. DOI:10.1021/acschembio.0c00960
[2] Lee J, et al. The Promise and Peril of Chemical Probe Negative Controls. ACS Chem Biol. 2021 Apr 16;16(4):579-585. DOI:10.1021/acschembio.1c00036 |
| | NVS MLLT-1 Preparation Products And Raw materials |
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