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| Product Name: | MS-39 | | Synonyms: | L-Prolinamide, N-[11-[4-[3-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-1-piperazinyl]-1,11-dioxoundecyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | | CAS: | 2675490-92-1 | | MF: | C55H71ClFN9O7S | | MW: | 1056.73 | | EINECS: | | | Product Categories: | | | Mol File: | 2675490-92-1.mol |  |
| | MS-39 Chemical Properties |
| Boiling point | 1150.624±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.266±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 14.078±0.40(predicted) | | form | Solid | | color | White to off-white |
| | MS-39 Usage And Synthesis |
| Uses | MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(piperazin-1-yl)propoxy)quinazolin-4-amine (HY-W109039) (red part), E3 ligase ligand (S,R,S)-AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC-CO-C9-acid (HY-139345). MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells[1]. | | References | [1] Cheng M, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63(3):1216-1232. DOI:10.1021/acs.jmedchem.9b01566 |
| | MS-39 Preparation Products And Raw materials |
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