ALK-IN-21 manufacturers
- ALK-IN-21
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- $1980.00
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2026-05-11
- CAS:2901889-01-6
- Purity:
- Supply Ability: 10g
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| | ALK-IN-21 Basic information |
| Product Name: | ALK-IN-21 | | Synonyms: | ALK-IN-21;4-Thiomorpholinecarbodithioic acid, 2-[4-[4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]-2-oxoethyl ester, 1,1-dioxide | | CAS: | 2901889-01-6 | | MF: | C35H45ClN6O6S4 | | MW: | 809.49 | | EINECS: | | | Product Categories: | | | Mol File: | 2901889-01-6.mol |  |
| | ALK-IN-21 Chemical Properties |
| Boiling point | 970.837±75.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.385±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 3.685±0.10(predicted) |
| | ALK-IN-21 Usage And Synthesis |
| Uses | ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC50 values of 4.59 nM, 2.07 nM and 5.95 nM toward ALKWT, ALKL1196M and ALKG1202R, respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC50 values of 0.07 μM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma[1]. | | References | [1] Xinyue Wang, et al. Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel ALK inhibitors. Bioorg Med Chem. 2022 Jul 15;66:116794. DOI:10.1016/j.bmc.2022.116794 |
| | ALK-IN-21 Preparation Products And Raw materials |
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