| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Dim16
CAS:2743448-32-8
Package:1removed
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Dim16 manufacturers
- Dim16
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- $3280.00
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2026-05-11
- CAS:2743448-32-8
- Purity:
- Supply Ability: 10g
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| Product Name: | Dim16 | | Synonyms: | Dim16;[2,4′-Bi-1H-imidazole]-3′-pentanamine, 1-(4,4-dimethylpentyl)-2′-iodo-N-methyl-5-(2-naphthalenyl)- | | CAS: | 2743448-32-8 | | MF: | C29H38IN5 | | MW: | 583.55 | | EINECS: | | | Product Categories: | | | Mol File: | 2743448-32-8.mol |  |
| | Dim16 Chemical Properties |
| Boiling point | 703.887±70.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.326±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 10.694±0.10(predicted) |
| | Dim16 Usage And Synthesis |
| Uses | Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells[1]. | | References | [1] Lammi C, et al. Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity. J Med Chem. 2023 Jun 22;66(12):7943-7958. DOI:10.1021/acs.jmedchem.3c00279 |
| | Dim16 Preparation Products And Raw materials |
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