斑蝥酸
| 中文名称 | 斑蝥酸 |
|---|---|
| 中文同义词 | 斑蝥酸;CANTHARIDIC ACID,PP2A AND PP1抑制剂 |
| 英文名称 | CANTHARIDIC ACID |
| 英文同义词 | 5'-3'2,3-DICARBOXY-2,3-DIMETHYL-1,4-EPOXYCYCLOHEXANE;CANTHARIDIC ACID;CANTHARIDIC ACID DISODIUM SALT;EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYCLO[2,2,1]HEPTANE;EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYLCO[2,2,1]HEPTANE;Cantharidic Acid - CAS 28874-45-5 - Calbiochem;7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 2,3-dimethyl-, (1R,2S,3R,4S)-rel-;Cantharidic acid, PP2A and PP1 inhibitor |
| CAS号 | 28874-45-5 |
| 分子式 | C10H14O5 |
| 分子量 | 214.22 |
| EINECS号 | |
| 相关类别 | Phosphatase InhibitorsPost-Translational Modification;Phosphatase InhibitorsSerine/Threonine Kinase Biology;Protein Phosphatase 1 (PP1)Enzyme Inhibitors by Enzyme;Protein Phosphatase, PP1 and PP2A;Serine/Threonine Phosphatase Inhibitors;Cell Signaling and Neuroscience;Kinase/Phosphatase Biology;P to;Phosphorylation Analysis |
| Mol文件 | 28874-45-5.mol |
| 结构式 |  |
斑蝥酸 性质
| 熔点 | 216-218℃ |
|---|---|
| 沸点 | 407.8±40.0 °C(Predicted) |
| 密度 | 1.359±0.06 g/cm3(Predicted) |
| 储存条件 | +15C to +30C |
| 溶解度 | 可溶于 DMSO (100 mM) 和乙醇（25 mM，温和加热） |
| 形态 | 白色固体 |
| 酸度系数(pKa) | 3.70±0.40(Predicted) |
| 颜色 | white |
| InChI | InChI=1/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10- |
| InChIKey | NMTNUQBORQILRK-XCVPVQRUNA-N |
| SMILES | [C@@]12([H])O[C@@]([H])(CC1)[C@](C)(C(O)=O)[C@]2(C)C(O)=O |&1:0,3,7,12,r| |
斑蝥酸是针对蛋白磷酸酶2A的有效抑制剂（IC50 = 50 nM）。
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 38 |
| 安全说明 | 22-36/37/39 |
| WGK Germany | WGK 3 |
| 存储类别 | 11 - 可燃固体 |