| Company Name: |
Shenzhen Botel Biotechnology Co. Ltd.
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| Tel: |
13316949107 13316968096 |
| Email: |
1979313431@qq.com |
| Products Intro: |
Product Name:Cantharidic Acid
CAS:28874-45-5
Purity:98% HPLC Package:10mg;25mg;50mg
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| | CANTHARIDIC ACID Basic information |
| Product Name: | CANTHARIDIC ACID | | Synonyms: | 5'-3'2,3-DICARBOXY-2,3-DIMETHYL-1,4-EPOXYCYCLOHEXANE;CANTHARIDIC ACID;CANTHARIDIC ACID DISODIUM SALT;EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYCLO[2,2,1]HEPTANE;EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYLCO[2,2,1]HEPTANE;Cantharidic Acid - CAS 28874-45-5 - Calbiochem;7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 2,3-dimethyl-, (1R,2S,3R,4S)-rel-;Cantharidic acid, PP2A and PP1 inhibitor | | CAS: | 28874-45-5 | | MF: | C10H14O5 | | MW: | 214.22 | | EINECS: | | | Product Categories: | Phosphatase InhibitorsPost-Translational Modification;Phosphatase InhibitorsSerine/Threonine Kinase Biology;Protein Phosphatase 1 (PP1)Enzyme Inhibitors by Enzyme;Protein Phosphatase, PP1 and PP2A;Serine/Threonine Phosphatase Inhibitors;Cell Signaling and Neuroscience;Kinase/Phosphatase Biology;P to;Phosphorylation Analysis | | Mol File: | 28874-45-5.mol |  |
| | CANTHARIDIC ACID Chemical Properties |
| Melting point | 216-218℃ | | Boiling point | 407.8±40.0 °C(Predicted) | | density | 1.359±0.06 g/cm3(Predicted) | | storage temp. | +15C to +30C | | solubility | Soluble in DMSO (100 mM) and in ethanol (25 mM, gentle warming) | | form | White solid | | pka | 3.70±0.40(Predicted) | | color | white | | InChI | InChI=1/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10- | | InChIKey | NMTNUQBORQILRK-XCVPVQRUNA-N | | SMILES | [C@@]12([H])O[C@@]([H])(CC1)[C@](C)(C(O)=O)[C@]2(C)C(O)=O |&1:0,3,7,12,r| |
| | CANTHARIDIC ACID Usage And Synthesis |
| Uses | Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway[1]. | | Definition | ChEBI: A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A. | | Biological Activity | Cell permeable: no', 'Primary Target
PP2A', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 50 nM against protein phosphatase 2A | | storage | Room temperature | | References | [1] Chen YC, et al., Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. DOI:10.1002/tox.22897 |
| | CANTHARIDIC ACID Preparation Products And Raw materials |
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