22-(4′-py)-JA

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

22-(4′-py)-JA manufacturers
22-(4′-py)-JA Basic information
Product Name:22-(4′-py)-JA
Synonyms:22-(4′-py)-JA;4-Pyridinecarboxylic acid, [(6S,7R,9R,14aS,15R)-7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl ester
CAS:1178895-15-2
MF:
MW:598.6
EINECS:
Product Categories:
Mol File:1178895-15-2.mol
22-(4′-py)-JA Structure
22-(4′-py)-JA Chemical Properties
Boiling point 833.186±65.00 °C(Press: 760.00 Torr)(predicted)
density 1.455±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka3.022±0.10(predicted)
Safety Information
MSDS Information
22-(4′-py)-JA Usage And Synthesis
Uses22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC)[1].
References[1] Iksen I, et al. Preclinical Characterization of 22-(4'-Pyridinecarbonyl) Jorunnamycin A against Lung Cancer Cell Invasion and Angiogenesis via AKT/mTOR Signaling. ACS Pharmacol Transl Sci. 2023 Jul 25;6(8):1143-1154. DOI:10.1021/acsptsci.3c00046
22-(4′-py)-JA Preparation Products And Raw materials
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