Antitumor agent-73 manufacturers
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| | Antitumor agent-73 Basic information |
| Product Name: | Antitumor agent-73 | | Synonyms: | Antitumor agent-73;Spirost-5-en-3-ol, 3-[5-(tricyclohexylphosphonio)pentanoate], bromide (1:1), (3β,25R)- | | CAS: | 2812356-72-0 | | MF: | C50H82O4P.Br | | MW: | 858.06 | | EINECS: | | | Product Categories: | | | Mol File: | 2812356-72-0.mol |  |
| | Antitumor agent-73 Chemical Properties |
| | Antitumor agent-73 Usage And Synthesis |
| Uses | Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin[1]. | | IC 50 | STAT3 | | References | [1] Wang L, et al. Synthesis and Antitumor Activity of Diosgenin Hydroxamic Acid and Quaternary Phosphonium Salt Derivatives. ACS Med Chem Lett. 2022 Apr 19;13(5):786-791. DOI:10.1021/acsmedchemlett.1c00581 |
| | Antitumor agent-73 Preparation Products And Raw materials |
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