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| | d-(KLAKLAK)2, Proapoptotic Peptide Basic information |
| Product Name: | d-(KLAKLAK)2, Proapoptotic Peptide | | Synonyms: | d-(KLAKLAK)2, Proapoptotic Peptide;D-Lysinamide, D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-leucyl-D-alanyl-;d-(KLAKLAK)2 | | CAS: | 721397-24-6 | | MF: | C72H139N21O14 | | MW: | 1523.01 | | EINECS: | | | Product Categories: | | | Mol File: | 721397-24-6.mol |  |
| | d-(KLAKLAK)2, Proapoptotic Peptide Chemical Properties |
| Boiling point | 1700.4±65.0 °C(predicted) | | density | 1.147±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 13.42±0.46(predicted) | | Sequence | {d-(Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys)}-NH2 |
| | d-(KLAKLAK)2, Proapoptotic Peptide Usage And Synthesis |
| Uses | d-(KLAKLAK)2, as an antibacterial and anti-tumor polypeptide, is a representative of the antimicrobial peptide group, and also has good anticancer properties. d-(KLAKLAK)2 is able to kill bacteria by damaging their cell membranes, causing cell contents to leak out. d-(KLAKLAK)2 can also inhibit tumor cell proliferation by causing mitochondrial swelling and mitochondrial membrane destruction, triggering apoptosis (programmed cell death)[1]. | | References | [1] Jaber S, et al. Synthesis, antitumor and antibacterial studies of new shortened analogues of (KLAKLAK) 2-NH2 and their conjugates containing unnatural amino acids[J]. Molecules, 2021, 26(4): 898. DOI:10.3390/molecules26040898 |
| | d-(KLAKLAK)2, Proapoptotic Peptide Preparation Products And Raw materials |
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