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| Boiling point | 1400.782±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.381±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | Sequence | Gln-{Htp}-{β-Ala}-{Nva}-Gly-His-NH2 |
| Uses | GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1]. | | IC 50 | RDC Peptide | | References | [1] Tu Y, et al. Novel GRPR-Targeting Peptide for Pancreatic Cancer Molecular Imaging in Orthotopic and Liver Metastasis Mouse Models. Anal Chem. 2023 Aug 1;95(30):11429-11439. DOI:10.1021/acs.analchem.3c01765 |
| | GB-6 Preparation Products And Raw materials |
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