N-4′-(p-Trifluoromethylphenyl)butyl-DAB

N-4′-(p-Trifluoromethylphenyl)butyl-DAB Suppliers list

Company Name:	Biorbyt Ltd.
Tel:	+44 (0)1223 859 353
Email:	info@biorbyt.com
Products Intro:	Product Name:N-4′-(p-Trifluoromethylphenyl)butyl-DAB

N-4′-(p-Trifluoromethylphenyl)butyl-DAB Basic information

Product Name:	N-4′-(p-Trifluoromethylphenyl)butyl-DAB
Synonyms:	N-4′-(p-Trifluoromethylphenyl)butyl-DAB;3,4-Pyrrolidinediol, 2-(hydroxymethyl)-1-[4-[4-(trifluoromethyl)phenyl]butyl]-, (2R,3R,4R)-
CAS:	3033570-20-3
MF:	C16H22F3NO3
MW:	333.35
EINECS:
Product Categories:
Mol File:	3033570-20-3.mol

N-4′-(p-Trifluoromethylphenyl)butyl-DAB Chemical Properties

Boiling point	457.2±45.0 °C(predicted)
density	1.296±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	14.06±0.60(predicted)

Safety Information

MSDS Information

N-4′-(p-Trifluoromethylphenyl)butyl-DAB Usage And Synthesis

Uses	N-4′-(p-Trifluoromethylphenyl)butyl-DAB (compound 5g) is an agonit of lysosomal acid α-glucosidase (GAA). N-4′-(p-Trifluoromethylphenyl)butyl-DAB increases intracellular GAA activities dose-dependently, in Pompe patient's fibroblasts with the M519V mutation[1].
References	[1] Kato A, et al. Design and Pharmacological Chaperone Effects of N-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase. J Med Chem. 2023 Jul 13;66(13):9023-9039. DOI:10.1021/acs.jmedchem.3c00637

N-4′-(p-Trifluoromethylphenyl)butyl-DAB Preparation Products And Raw materials

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