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| | Neuraminidase-IN-18 Basic information |
| Product Name: | Neuraminidase-IN-18 | | Synonyms: | Neuraminidase-IN-18;Acetamide, N-[(4-fluorophenyl)methyl]-2-[[5-[(2-naphthalenyloxy)methyl]-1,3,4-oxadiazol-2-yl]thio]- | | CAS: | 2935407-32-0 | | MF: | C22H18FN3O3S | | MW: | 423.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2935407-32-0.mol |  |
| | Neuraminidase-IN-18 Chemical Properties |
| density | 1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 13.34±0.46(predicted) |
| | Neuraminidase-IN-18 Usage And Synthesis |
| Uses | Neuraminidase-IN-18 (compound N5) is a novel polyheterocyclic neuraminidase (NA) inhibitor. Neuraminidase-IN-18 shows potency in inhibition of H5N1 NA with an IC50 of 0.14μM and 0.27μM against the wild-type H5N1 NA and H5N1-H274Y mutant NA, respectively. Neuraminidase-IN-18 inhibits influenza virus replication by binding to NAs in cell level[1]. | | References | [1] Lin Lin Shang, et al. Discovery of novel polyheterocyclic neuraminidase inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone. European Journal of Medicinal Chemistry, Available online 12 March 2024, 116305. |
| | Neuraminidase-IN-18 Preparation Products And Raw materials |
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