| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:TLR8 agonist 9
CAS:3034750-61-0
Package:50mg/RMB 25800
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Email: |
info@biorbyt.com |
| Products Intro: |
Product Name:TLR8 agonist 9
CAS:3034750-61-0
|
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| | TLR8 agonist 9 Basic information |
| Product Name: | TLR8 agonist 9 | | Synonyms: | TLR8 agonist 9;3H-1-Benzazepine-4-carboxamide, 2-amino-8-[1-[[[6-[[2-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-1,3-dioxan-5-yl]carbonyl]-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl]amino]carbonyl]cyclopropyl]-N-(2-hydroxyethyl)-N-propyl- | | CAS: | 3034750-61-0 | | MF: | C38H43N7O8 | | MW: | 725.79 | | EINECS: | | | Product Categories: | | | Mol File: | 3034750-61-0.mol |  |
| | TLR8 agonist 9 Chemical Properties |
| density | 1.48±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 13.41±0.20(predicted) |
| | TLR8 agonist 9 Usage And Synthesis |
| Uses | TLR8 agonist 9 (Compound II-77) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 9 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 9 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 97%[1]. | | IC 50 | TLR8 | | References | [1] Zhang W, et al., Benzazepine derivative, conjugate containing same, and use thereof. WO2024067841A1. |
| | TLR8 agonist 9 Preparation Products And Raw materials |
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